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Despite the relatively large sample size, our power to detect modest associations may still have been limited, especially for evaluating differences by advanced and/or multiple adenoma status and anatomical subsite.
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The multiple adenoma (≥3 adenomas) detection rate was 14%.
Of the 178 multiple adenoma cases, 103 had ≥10 adenomas and 75 had 5 9 adenomas.
Immunohistochemistry was performed on the multiple adenoma group, sporadic adenomas and, for comparison, a set of patients with FAP.
The outcome variable of adenoma status was determined by the highest grade lesion identified.
These three SNPs alone explained ∼3% of the variance in multiple adenoma risk.
The main predictive factors for proximal location proved to be both the diagnosis period and the number of adenomas detected at each endoscopic exam (single adenoma versus multiple adenoma).
No significant associations were observed between adenoma status and center, race/ethnicity, glucose tolerance status, BMI, NSAID use, and smoking status.
Furthermore, no association between adenoma status and alterations in systemic chemokines (RANTES, MCP-1) were observed in this study.
Logistic regression models were used to examine the association between adenoma status and insulin, C-peptide, IGFBP-1 or apoptosis.
In conclusion, although unidentified Mendelian predisposition genes for multiple adenomas may exist, we have shown that common CRC risk variants are likely to contribute to the multiple adenoma phenotype.
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