Sentence examples for multiple adenoma cases from inspiring English sources

Of the 178 multiple adenoma cases, 103 had ≥10 adenomas and 75 had 5 9 adenomas.

It is highly plausible that some of the multiple adenoma cases carry additional, unknown susceptibility variants with moderate or small effects.

Multiple adenoma cases in whom the known Mendelian syndromes have been excluded are often not clinically distinguishable from the Mendelian conditions of attenuated FAP, MAP or PPAP.

As a more general test of the hypothesis that common risk alleles contribute to the multiple adenoma phenotype, we compared the SNP risk score distributions in multiple adenoma cases and controls.

The risk of CRC in relatives of multiple adenoma cases is probably much lower for cases with polygenic disease, and this should be taken into account when counselling such patients.

There was a significantly higher risk score (P=5.8 × 10−7, t-test; Table 1 and Figure 1) in multiple adenoma cases (mean=2.44, SD=0.40) than controls (mean=2.27, SD=0.42).

No multiple adenoma case had an outlying number of CRC SNP risk alleles, but multiple adenoma patients did have a significantly higher number of risk alleles than population controls (P=5.7 × 10−7).

Our other four previously reported adenoma SNPs (rs10936599, rs4444235, rs1957636, rs4939827, rs961253) were not as well supported by this study or by Hes et al (details not shown), although this might have resulted from the relatively small sizes and low power of the two multiple adenoma case collections.

A further consideration is that a small number of our multiple adenomas cases may have carried germline variants in the mismatch repair genes (MSH2, MLH1, MSH6, PMS2) or the juvenile polyposis genes (SMAD4, BMPR1A).

We compared plasma and rectal mucosal cytokines between cases with one versus multiple adenomas, cases with at least one adenoma of at least 1 cm in size versus all adenomas less than 1 cm in size, and cases with at least one adenoma with villous component versus all adenomas having only tubular components, using Mann–Whitney U test.

Risk estimates for advanced and/or multiple adenoma (323 cases) were not statistically significant for red (OR=1.32, 95% CI=0.91 1.94) or processed meat (OR=1.12, 95% CI=0.76 1.65).