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In addition to microtubule nucleation at centrosomes, it is now becoming clear that multiple additional sites for microtubule nucleation exist within the mitotic cell.
Of note, the CNTNAP2 gene locus is one of the largest in the genome and could potentially contain multiple additional sites with functional relevance to neurodevelopmental phenotypes, to be clarified in future with high-density SNP screening and sequence-based strategies.
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Further, all 25 top CpGs were in larger differentially methylated regions that included multiple additional CpG sites for which DNA methylation levels were correlated (r ≥ 0.8; median number of CpGs per region = 5, range 2 10).
For example, each division had the freedom to enter a tissue request for tissue from multiple sites from a single donor as one tissue request for multiple sites, with the additional sites listed in a comment, or as multiple tissue requests, one for each site.
Here we show that RNAi-mediated silencing of DYRK1A expression simultaneously affects multiple additional AD-relevant tau phosphorylation sites, including threonine 231 and serine 396 (Figure 1).
On a broader scale, through the use of Pol β we continue to develop a more precise understanding of the basis of DNA polymerase fidelity by establishing our techniques as a systematic framework of investigation that can be applied to multiple polymerases and additional site-specific mutants (42) during both matched and mismatched nucleotide incorporations.
In addition to the promoter sites upstream of the eight identified transcription units, multiple additional sequences conforming to the promoter consensus were found.
Further testing at additional sites to calibrate single- and multiple-species growth and identify any spatial trends in model performance will also be beneficial.
Thus, some additional sites were excluded because no one variant (out of the multiple variants present at the site) was present in at least three reads.
As a result, the building is one of the 5 additional sites of P721M, a school for older (aged 15 21) students with multiple disabilities and mental retardation.
In order to better understand spatial heterogeneity of PM2.5 constituents in Denver, we have carried out supplemental monitoring at three additional sites for 1 year and plan to compare the PM2.5 constituent time series across these multiple monitoring sites.
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