Sentence examples for multiple activation states from inspiring English sources

A detailed understanding of inhibitor binding therefore requires characterizing interactions across multiple activation states.

Therefore, the two-state model is a reasonable approximation of GPCR activation and multiple activation states may be considered as a perturbation to the two-state model.

As the expression of α5β1 integrin is ubiquitous in the Xenopus embryo, the differential use of α5β1 by ectoderm, endoderm and mesoderm suggests that this integrin exists in multiple activation states.

What are the implications of these multiple activation states of Btk and its role in cancer?

It is important to note that multiple active states are not sequential steps in the activation process.

Although multiple active states have been proposed to explain so-called biased-signaling phenomena (Onaran et al. 2014), the two-state model remains the cornerstone of the GPCR activation study: the free-energy differences and energy barriers between the multiple active states are usually significantly smaller than those between the ground and active states.

Aging of the innate immune system is complex in spanning multiple cell types, activation states, and tissue context, and, while incompletely understood, it is characterized by dysregulation and inappropriate persistence of inflammatory responses [ 1].

Absence of allostery in the active state may be a general feature of RTKs whose activity is enhanced by multiple activation loop phosphorylations, including FGFR, Met, VEGFR, Alk, MUSK, Kit, and their homologs (Lemmon and Schlessinger, 2010).

Microglia mediate multiple facets of neuroinflammation, including cytotoxicity, repair, regeneration, and immunosuppression due to their ability to acquire diverse activation states, or phenotypes.

Fig. 6 Structural variabilities and activation states of the targets.

We next examined the activation states of downstream signaling molecules.