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The results of our present study showed that DHA, an omega-3 FA, has a strong anticancer activity in cultured MCF-7 human breast cancer cells through a combination of multiple actions, including inhibition of DNA synthesis, suppression of cell viability, and induction of apoptotic cell death.
Activated AMPK may have multiple actions including the activation of eNOS via phosphorylation at Ser [ 16, 17].
Acorus calamus prevented CCI induced neuropathy which may be attributed to its multiple actions including anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory actions.
This suppressive effect is mediated through multiple actions including decreased fibroblast proliferation, decreased collagen I and III production, and increased collagen degradation.
The profibrotic effects of TGF- β are mediated by its multiple actions, including induction of myofibroblasts, increase of matrix synthesis, and inhibition of collagen breakdown.
7 Against this backdrop, the struggle for social justice requires multiple actions, including an increase in availability of and access to a range of mental health services.
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The Jordan Valley exemplifies the pressure of multiple human actions including intensive livestock grazing and agriculture on bird diversity.
Recent studies have demonstrated their multiple pharmacologic actions, including anti-inflammatory, anti-allergic and antibacterial effects; promoting gastrointestinal motor function; and inhibiting cancer cell growth in vitro.
10 GH has multiple physiological actions, including the promotion of linear growth in childhood, and is essential for the maintenance of normal body composition throughout life.
Endothelin-1 has multiple cardiovascular actions, including vasoconstriction, leading to maintenance of basal vascular tone and BP (Haynes and Webb 1998) and accentuating BP elevation in more severe, sodium-sensitive hypertension (Schiffrin 2001).
Phytochemicals screening have confirmed the presence of flavonoids, saponins and terpenoids, all these classes of phytochemicals are responsible for multiple pharmacological actions including anti-inflammatory activity [ 24– 26].> -wrap-foot> > -wrap-foot> > -wrap-foot> ethylthyl acetate fraction, PGE 2 prostaglandin E2.
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