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Previously, we discovered that 4- N -stearoyl gemcitabine solid lipid nanoparticles (4- N -stearoylLNs) can overcome multiple acquired gemcitabine resistance mechanisms, including RRM1 overexpression.
We presume that the cancer cell genome has several, if not multiple acquired defects in genes for proteins controlling cell cycle, rendering cancer cells less tolerant than normal cells to modulation of phosphorylation mediated through signal transduction [21], [28].
Genes coding for carbapenemases are usually co-located with multiple acquired resistance determinants, leaving few effective, low toxicity or non-parenteral options for therapy [ 17].
All these strains also contained multiple acquired antibiotic resistance genes challenging the hypothesis of Palmer and Gilmore [ 146] that multidrug resistant enterococci generally lack CRISPR- cas genes.
Musashi-1 facilitates malignant transformation through multiple acquired chromosomal aberrations (Siebzehnrubl et al, 2009) and is a CSC marker in tumours (Hemmings, 2010).
This definition should be distinguished from an image phenotype which is a set of multiple acquired quantitative measurements obtained from digital imaging data as parameters for personalized characterization of the subject examined.
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Somewhere between "2,000-10,000" of those involved multiple communications acquired in single collections, such as the e-mail inbox screenshots.
Dementia can also be caused by Huntington disease, syphilis, multiple sclerosis, acquired immune deficiency syndrome (AIDS), and some types of encephalitis.
Time-resolved spectral measurements were conducted on the plasma flash with multiple frames acquired with a 10 μs gating interval.
Kumar et al. [4] have proposed a finger knuckle recognition algorithm using multiple patterns acquired from the index, middle, ring, and little fingers.
This fact is demonstrated on multiple lines acquired near upholes, and agreement between the seismic velocities and the upholes is high.
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