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This observation of lipodystrophy is very much in agreement with the effect of HIV pathogenesis in humans, as the virus is known to induce multiple abnormalities including insulin resistance, lipodystrophy and weight loss.
Cancer cells show multiple abnormalities, including inherent replication stress and DNA damage.
Finally, F13 had multiple abnormalities including a multicystic-dysplastic kidney, distorted ribs and spine, brain defects and bilateral talipes equinovarus.
There were multiple abnormalities, including osteopenia, characterized by the loss of most trabecular bone at the metaphyses (data not shown).
The recurrent tumor stem lines also contain very complex karyotypes with multiple abnormalities including non-reciprocal translocations, deletions, duplications and marker chromosomes.
Gene disruption is associated with multiple abnormalities, including low bone mass, in KO mice, and the spondylocheiro dysplastic form of Ehlers Danlos syndrome in humans.
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HIV-infected patients develop multiple metabolic abnormalities including insulin resistance, lipodystrophy and dyslipidemia.
Together, this suggests that OPA1 mutations cause multiple organ abnormalities, including auditory neuropathy, peripheral neuropathy (apoptosis and ophthalmoplegia), cardiomyopathy and myopathy, suggesting that OPA1 could be a common target for treatment of mitochondria-related disorders.
Furthermore, haplo-insufficiency of SOX9 in humans causes campomelic dysplasia involving multiple developmental abnormalities including those in cartilage (44).
Hypothermia is associated with multiple physiological abnormalities including reduced myocardial contractility, peripheral vasoconstriction, increased infection risk and impaired coagulation [ 1].
One of these disorders, ataxia-telangiectasia (A-T), is characterized by multiple physiologic abnormalities, including neurodegeneration, immunologic abnormalities, cancer predisposition, sterility, and metabolic abnormalities.
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