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A remarkable feature of malformations in vertebrates including man is the association of multiple abnormalities in complex syndromes.
The Fanconi syndrome is a group of diseases in which there are multiple abnormalities in renal-tubular function.
Lck-GM-CSF transgenic mice displayed a dramatic phenotype, characterized by splenomegaly, lymphadenopathy, thymic atrophy, and multiple abnormalities in blood cell populations.
Specifically, the report says the EPA's Midwest branch knew in June 2015 that Flint hadn't treated its water correctly and that "residents had reported multiple abnormalities in the water, and test results from some homes showed lead levels above the federal action level".
Importantly, knocking down TPP1 led to multiple abnormalities in zebrafish embryogenesis, including neural death, heart malformation, and caudal defect.
TRAF2-, 3-, 6-deficient mice die in utero or shortly after birth, suffering from multiple abnormalities in various organs.
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Multiple abnormalities occur in polyostotic fibrous dysplasia, in which affected bone is replaced by fibrous connective-tissue matrix.
Therefore, it is important to note that even when adipocytes are infected by HIV in vivo, the multiple abnormalities seen in adipose tissues of HIV-1-infected individuals are not due to the replication of HIV in adipocytes per se.
In SSc fibroblasts, multiple abnormalities occur in the SMAD signaling pathways.
In contrast, retinal microvessels of sEng-expressing mice were characterized by multiple abnormalities, particularly in the superficial vascular plexus.
Neuroanatomical studies have reported multiple abnormalities including changes in both gray and white matter in the temporal lobe, including the amygdala and hippocampus.
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