Sentence examples for multiple aberrations in from inspiring English sources
These processes are prone to multiple aberrations in cancers with varying outcomes.
A computational method designed to identify driver mutations within protein kinase datasets successfully identified multiple aberrations in the FGF/FGFR machinery [ 4].
In depth analysis revealed that, despite their responses, their tumors demonstrated multiple aberrations in genes including CCND1, CCNE1, FGFR1, MYC, IRS2, MCL1, PIK3CA, PIK3R1, PRKDC, and TP53.
Malignant gastric tumors are known to carry multiple aberrations in their genome and such chromosomal alterations are crucial for the activation and inactivation of cancer-related genes [ 8- 17].
Therefore, in an attempt to predict preferential benefit from combined AKT inhibitor/trastuzumab therapy, exploratory biomarker analyses may need to consider the polygenic nature of trastuzumab resistance and assess multiple aberrations in the HER2 signaling pathway in each tumor.
Our results show multiple aberrations in pro- and anti-inflammatory signaling pathways of lymphocytes, determined by phospho-specific whole blood flow cytometry, in AP patients with vital organ dysfunction and immune suppression.
Our data show, for the first time, that in acute pancreatitis complicated by vital organ dysfunction multiple aberrations occur in lymphocyte signaling profiles.
Comparative genomic hybridisation microarray (arrayCGH) analysis of p16INK4a-positive CIN2/3 demonstrated two subsets, one showing few chromosomal aberrations and the second subset containing multiple aberrations akin to those found in cervical carcinomas [ 21].
Although in some cases individual genomic aberrations may drive disease development in isolation, a complex interplay among multiple aberrations is common.
Cells with more than four of the same type of aberration were scored as multiple aberrations.
In patient #2, who also achieved a durable PR (14 months) on anastrozole and everolimus, multiple aberrations were seen as well.
