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QPc.crc-14D is well marked with multiple SNPs underlying the genetic region.
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The cod α-β globin clusters were mapped to different linkage groups by genotyping multiple single nucleotide polymorphic (SNP) markers, including the globin SNPs underlying the Metβ1Val and Thrα2Ile polymorphisms [ 27].
For SNPs with significant replication, Locus Zoom55 was used to generate regional plots of the stage-1 data to show the pattern of association surrounding the index SNP with respect to LD with neighbouring SNPs, underlying recombination rate and gene context (Fig. 4).
Single nucleotide polymorphisms (SNPs) underlie disease susceptibility through their effects on protein function and gene expression.
The logic underlying this analysis is that multiple SNPs within a region of a chromosome harbouring a QTL may provide strong signal, and thus, the total number of genome-wide SNPs associated with a trait provides an overestimate of the number of QTL that create variation in the trait.
Unlike other types of genotyping error, unidentified copy number variants (CNVs) could produce spurious TDT signals that span multiple SNPs; however, there are a number of lines of evidence against CNVs underlying our strongest signals.
There were four discrete genomic windows containing multiple SNPs with elevated FST values (Table 2).
The established method is accurate and can be used to type multiple SNPs simultaneously.
Thicker or uneven red lines result from multiple SNPs in close proximity or shifts due to small indels.
In the case of previously described susceptibility loci we include the reported psoriasis SNP, or multiple SNPs where independent effects have been observed, as covariates in the regression model.
This method, restriction-enzyme-mediated single-base extension, is demonstrated by typing multiple SNPs simultaneously for 44 DNA samples.
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