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Monotherapy with levofloxacin (500 mg every 12 hours) was compared with combination therapy (ofloxacin 200 mg every 12 hours plus cefotaxime 1 g every 8 hours) in a multinational trial of 398 patients with CAP who required ICU admission, but who required neither vasopressors nor mechanical ventilation [33].

ATTRACT was a 2-year, multicenter, multinational trial of 428 patients with active RA despite methotrexate therapy.

Bollen and coworkers [ 6] reported the results of a multi-centre, multinational trial of the safety and efficacy of high-frequency oscillatory ventilation (HFOV) in ARDS patients.

Future work, ideally within a multinational trial of the same disease profile, to compare parental attitudes within different health care systems would be interesting.

The reference clinical trial 23 used in the model was a doubleblind, randomized, multinational trial of CINV preventative therapy, completed in 2008 (National Clincial Trials registry number: NCT00337727).

The Second Line study is a 96-week, multinational trial of participants virologically failing first-line therapy randomized 1 : 1 to currently recommended second line treatment 2-3N t RTII + LPV/r) or RAL (400 mg b.i.d).

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Safety and efficacy data were collected from two randomized, multinational trials of LAIV and TIV in children aged 6 71 months [ 4, 8].

Safety and efficacy data were collected for children aged 2 5 years with asthma or prior wheezing from two randomized, multinational trials of LAIV and TIV (N = 1,940).

For example, for a large multicenter multinational trial to decrease the probability of a beta error (for example, increase the power) from 0.20 to 0.10, the result would be greater recruitment, an increase in the number of patients exposed to placebo interventions, and possibly result in a multi-million dollar increase in cost.

We analysed pooled data from the multinational trials to obtain the most precise estimates of the magnitude of treatment effect on measures of disease progression.

This study is a retrospective analysis of data derived from a randomized, active-controlled, assessor-blind, multicentre, multinational trial; the details of which have been described previously (Nyboe Andersen et al., 2006).

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