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A multinational trial (APRICOT) showed that peginterferon alfa-2a (40 kDa) plus ribavirin is efficacious for treatment of HIV HCV co-infection.
METHODS: We studied patients with advanced lung cancer who have been observed longitudinally with x-ray computed tomography in a multinational trial.
Then in 2009, a 35,553-man multinational trial of selenium and vitamin E, alone or in combination, reported that neither selenium nor vitamin E had any benefit against prostate cancer.
The OPERA trial is an appropriately powered, investigator-initiated, randomized, double-blind, placebo-controlled, multinational trial to determine whether perioperative oral ω-3-PUFAs reduces occurrence of PoAF in patients undergoing cardiac surgery.
If benefits from CI do exist in critically ill patients, a large-scale, prospective, multinational trial with a robust design is required.
To further ascertain whether benefits of continuous infusion in critically ill patients do exist, a large-scale, prospective, multinational trial with a robust design is required.
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Secondary analysis of data were from two multinational trials (n=629; 765).
This review highlights the need for well-designed multinational trials aimed at the optimization and standardization of RT for limited-stage SCLC.
Although recommendations for conducting economic evaluations have been widely disseminated, relatively little guidance has been given for conducting economic evaluations alongside clinical trials, particularly multinational trials.
Provided sponsors capture both early and late outcomes in multinational trials, separate analyses for US and European authorities are possible, and the same study could satisfy both sets of requirements [18].
The final translation process documents are currently in use as guideline documents for member firms that are funding new language translations of PRO Consortium measures for use in their multinational trials.
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