We argue why future studies should rather be large multinational prospective observational trials and not necessarily randomised controlled trials.
The largest, most recent study is a double-blind, phase II, multicenter, multinational, prospective, randomized controlled trial of rFVIIa in trauma patients conducted during the period 2001 2003.
Two large multinational prospective randomised controlled trials (Freifeld et al, 1999; Kern et al, 1999) have demonstrated equivalence in terms of both efficacy and safety for oral antibiotics compared to standard parenteral regimens for patients with low-risk FN when delivered in the in-patient setting.
The SPACE trial is a multinational, prospective, randomised study to test the hypothesis that carotid artery stenting is not inferior to carotid endarterectomy for treating patients with severe symptomatic carotid artery stenosis.
Part 2 evaluated whether an IV+SC golimumab treatment strategy might boost the efficacy of the initial subcutaneous regimen in patients who achieved response but not remission in part 1. GO-MORE was an open-label, multinational (40 countries, 475 centres), prospective trial (protocol P06129; Ncomposed30) cofposed of two parts (figure 1).
The ACTICCA-1 study is a multinational, prospective, randomized, controlled phase III trial designed to assess the clinical performance of gemcitabine plus cisplatin and observation vs. observation alone in patients after curative intent resection of BTC (Fig. 1).
The Reduction by Dutasteride of Prostate Cancer Events REDUCEE) cancer prevention trial 8 is a large multinational prospective randomised study that measured prostate volume and urinary symptoms at baseline and included men with minimal or no lower urinary tract symptoms.
Asian patients were enrolled as part of a large multicenter, multinational, prospective, open study conducted from May 2006 to March 2007 (ClinicalTrial.gov identifier: NCT00312806), the full trial design details of which have been previously reported [ 4].
This was a randomised, controlled, prospective trial.
Our prospective trial had 2 objectives.
