This multinational, phase III clinical study in 22 European centres was undertaken to compare anti-granulocyte imaging using the murine IgG antibody besilesomab (Scintimun®) with 99mTc-labelled white blood cells in patients with peripheral osteomyelitis.
Zilver PTX was recently evaluated in a large multicenter, multinational randomized, controlled trial and a complementary multinational, multicenter, single-arm clinical study [ 13– 15].
We determined the history of ophthalmologist-diagnosed AU in 1250 patients with active AS who were enrolled in a multinational, open-label, uncontrolled clinical study of treatment with adalimumab, 40 mg every other week for up to 20 weeks.
As the use of functioning outcomes is increasingly being advocated in multinational clinical trials and comparative studies, making available instruments with known validity and reliability in several languages is required.
Since its publication in 1992 the WHQ has been widely used in multinational clinical trials, in epidemiological studies as well as in the evaluation of non-medical treatments.
This is a prespecified subanalysis of a multinational, prospective, open-label, uncontrolled clinical study of adalimumab 40 mg every other week for the treatment of patients with AS.
Baseline data from a subsample of 1,245 participants of the Multiple Outcomes of Raloxifene Evaluation study, a randomized, placebo-controlled, multinational clinical trial to evaluate the safety and efficacy of raloxifene, were analyzed.
The MORE study was a randomized, placebo-controlled, multinational clinical trial designed to evaluate the efficacy and safety of raloxifene.
The Multiple Outcomes of Raloxifene Evaluation study was a randomized, placebo-controlled, multinational clinical trial evaluating efficacy and safety of raloxifene.
A subsample of 1,245 PMO women participating in the Multiple Outcomes of Raloxifene Evaluation (MORE) study, which was a randomized, placebo-controlled, multinational clinical trial to evaluate the safety and efficacy of raloxifene [ 21], was utilized as the data source.
