Exact(1)
However, as previously shown [ 5], the best candidate gene-expression prognostic markers can also exhibit bimodal (or multimodal) profiles (ie, mixtures of Gaussians) within a given prognostic class, indicating that these phenotypes are themselves heterogeneous and that classification analysis should attempt to take this heterogeneity explicitly into account.
Similar(59)
Cheow LF, Courtois ET, Tan Y, Viswanathan R, Xing Q, Tan RZ, et al. Single-cell multimodal profiling reveals cellular epigenetic heterogeneity.
Given that most patients exhibit multiple metabolic aberrations, the multimodal profile of SGLT2 inhibitors is certainly refreshing.
As reasons for missing long-term effects of inpatient rehabilitation in Germany, different causes have been discussed by Hüppe et al., concerning masked effects, non-satisfying multimodal profile of treatment, missing individualization of treatment, insufficient treatment intensity and inadequate aftercare [ 11].
Based on the current preclinical understanding of the mechanisms and the preclinical and clinical results, we hypothesize that vortioxetine's multimodal profile including 5-HT3 and 5-HT7 antagonism, 5-HT1B pagonismandnism, and 5-HT1A agonism could result in enhanced glutamate transmission and contribute to its antidepressant and cognitive enhancing properties.
It is also shown that, when the relaxation or self-diffusion properties are multimodal, the 1D-profile of each water population is recovered.
We form a unimodial model of cell body depth and a multimodal synapse density profile model (see 'Materials and methods' for mathematical details).
These data further indicate that BCA can synergistically support multimodal therapies with a low toxic profile.
Therefore, these tests may serve well - and in fact are frequently used - as general screening methods, if necessary followed by more complex, multimodal assessment inventories such as the Physiological Profile Assessment (PPA) [ 28].
In DMF, both kinds of PUs have multimodal molar mass distributions, while the reduced viscosity concentration profiles indicate an upturn in very dilute regions usually related to the polyelectrolyte effect.
To clarify further association between each patient's profile and risk of AD conversion, multimodal analyses of data are needed for longer follow-up period.
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