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Most cluster randomized studies reported the unit of randomization [29 37] [39 41 44 45] and adjusted the treatment effect analysis for cluster randomization [29 37] [39 44]; whereas the ICC was formally reported only in the multimodal intervention trial by Cox et al. [38].
Recently, a relatively large, multimodal intervention trial targeting all age groups was conducted in four municipalities of Akita.
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The JFNMH conducts the program "Japanese Multimodal Intervention Trials for Suicide Prevention, J-MISP" in close collaboration with the National Center of Neurology and Psychiatry.
To respond to the rapid surge in the incidence of suicide in Japan, which appears to be an ongoing trend, the Japanese Multimodal Intervention Trials for Suicide Prevention (J-MISP) have launched a multimodal community-based suicide prevention program, NOCOMIT-J.
The Japanese Multimodal Intervention Trials for Suicide Prevention (J-MISP) includes a randomized, controlled, multicenter trial of post-suicide attempt case management for the prevention of further attempts (ACTION-J) to address the continuing increase in suicides in Japan.
Also in 2005, two research projects (Japanese Multimodal Intervention Trials for Suicide Prevention: J-MISP [ 7]) funded by The Japanese Ministry of Health, Labor and Welfare (JMHLW), were launched to develop effective strategies to prevent suicide.
A multimodal treatment trial is an additional challenge in a sparsely populated country like Norway.
Randomized controlled trial of a multimodal intervention designed to activate persons living with HIV.
J-MISP consists of a community intervention trial of a multimodal suicide prevention program (NOCOMIT) [ 8] and a randomized controlled multicenter trial of post-suicide attempt case management to prevent further attempts (ACTION-J).
A multimodal intervention was applied in a clinical trial in a group of moderate to severe COPD outpatients consisting in endurance physical exercises combined with oral nutritional supplements and oral testosterone undecanoate administration (80 mg or 40 mg twice daily for men and women, resp).
We use a pragmatic, randomized controlled trial to evaluate this multimodal intervention with the patient as the unit of randomization.
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