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These results demonstrate the potential of PEG 5 -BP-USPIOs for the develoPEG 5 -BP-USPIOsd multimodal imaging agents for molecular imaging.
Hence, it can be seen that multimodal imaging agents are available, but their clinical application still need further research.
Compared to small molecules, peptides, and large biomolecules, the modular design and multifunctionality of nanoparticles enables the straightforward integration of different imaging modalities into one imaging agent and has made them the most commonly used platform for multimodal imaging agents.
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These first preclinical results emphasize the potential of a dual-labeled PSMA inhibitor to serve as a multimodal imaging agent, enabling sensitive pre-, intra- and post-therapeutic identification of metastases with one and the same molecule.
With multimodality imaging techniques clearly on the rise, the development over these new techniques has led to explosive growth in multimodal imaging agent researches [ 74, 75].
In line with the recent development of fused instruments to perform multimodal imaging (PET/MRI (Magnetic Resonance Imaging), SPECT/CT or PET/CT (computed tomography), Fluorescence/MRI) [[9]], DOTA based Gd3+ complexes can be associated with other imaging agents, such as radionuclide chelators or organic luminescent probes [[10] [12]].
Future developments of dually labeled hybrid imaging agents for PET/OI exhibiting a favorable in vivo biodistribution and being applicable in a multimodal clinical setting face the challenge to introduce a radiolabel as well as a fluorescent reporter probe by at the same time preserving the favorable pharmacokinetic properties enabling a successful and specific target visualization.
Most of the imaging agents for inflammation imaging are SPECT imaging agents.
While the vast majority of imaging agents are specific to a single modality, recent years have played witness to a surge in the development of multimodal probes.
The availability of [18F] SF6 may also turn useful in multimodal imaging approaches, due the current use of SonoVue® (from Bracco), an SF6 microbubble formulation, as an ultrasound contrast imaging agent.
Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed.
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