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Another type of multimodality imaging is multimodal contrast agents, which integrate multiple properties within one nanoparticle to allow its detection with several imaging techniques [ 91].
Several works on nano-carriers, such as GO and LDH in developing multimodal contrast agents for MRI and CT as well as for simultaneous drug delivery to be used in theranostic applications showed promising results.
Hence, due to their high biocompatibility, superparamagnetic properties, and their high capacity for use as multimodal contrast agents, these functionalized magnetic nanoparticles are considered the most promising magnetic nanoparticles in nanomedicine, and more specifically, in the diagnosis of AD.
Promising new multimodal contrast agents now under investigation include MRI Raman photoacoustic nanoparticles [ 25] and C-Dots [ 26].
The need for complimentary diagnostic information has led to the emergence of multimodal contrast agents that are capable of generating contrast by different modalities, simultaneously.
Finally, if surgical resection is appropriate, multimodal contrast agents could be used for presurgical planning and intraoperative imaging to ensure the complete removal of the tumour [ 25].
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Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging.
Here, the true power of a multimodal contrast agent comes into play, in this case combining the in vivo MRI findings with ex vivo fluorescence microscopy.
To our knowledge, this is the first report of one-pot synthesis of Gd-doped GSS nanoparticulate contrast agents as well as the first example of a multimodal contrast agent for MRI and PAT.
Multimodality imaging has many advantages, but some problems still exist and need to be solved, such as the difficulty of designing a PET/MRI system suited for the entire body, cost increase, performance improvement, and multimodal contrast agent fusion.
To aid in the realization of these goals, an ideal theranostic nanocarrier should have excellent biocompatibility, good loading efficiency, therapeutic shielding capacity, and targeting capability and be amenable to multimodal contrast agent modification.
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