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Moreover, the V-antigen multifunctional virulence factor important for type III secretion system activity is expressed by the nlpD mutant during infection as reflected by development of αV antibodies following immunization of mice (Table 3 and 4).
Our finding that HcpA is a multifunctional virulence factor with the potential to simultaneously mediate innate immune evasion and degradation of extracellular matrix components significantly adds to our understanding of the pathological processes underlying louse-borne relapsing fever.
Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'tail
These data show that chitinase is a multifunctional virulence factor for L. mexicana which assists its survival in Lu. longipalpis.
In conclusion, this study identifies the Leishmania chitinase as a multifunctional virulence factor that benefits the parasite throughout its entire life cycle.
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Bacterial virulence is normally dependent on several factors, and presence of Pla, although it is an exceptionally multifunctional and powerful virulence factor [ 8, 10- 16, 19, 19, 26- 28, 30, 31] does not alone explain the devastating virulence of Y. pestis.
ClfA is a surface adhesin that binds to the C-terminus of the plasma fibrinogen γ chain., This interaction is central to the multifunctional activities of this well-characterized virulence factor.
Yersinia pestis, the causative agent of plague, encodes several essential virulence factors on a 70 kb plasmid, including the Yersinia outer proteins (Yops) and a multifunctional virulence antigen (V).
The leukotoxin from M. haemolytica is the predominant virulence factor.
The major virulence factor for STEC infection is Shiga toxin.
Glucosyltransferases (GTFs) represent a virulence factor of mutans streptococci.
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