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Skn7 is a multifunctional transcription factor, as reflected by its ability to partner a variety of other transcriptional regulators under different conditions.
YY1 is a ubiquitously expressed multifunctional transcription factor that has been shown to be involved in the regulation of a large number of genes that are critical for basic biological processes of cell growth, development, differentiation, cell cycle and even programmed cell death (apoptosis) (reviewed in [1], [2]).
Similarly, p53 that encodes a multifunctional transcription factor to mediate cellular responses to diverse stimuli, including apoptosis, DNA repair, and cell cycle arrest [9] [11] was also found to regulate the proteolytic capacity of various cells by directly controlling the expression of various MMPs [12] [14] and urokinase genes [15] [17].
As a multifunctional transcription factor, CHOP mediates gene expression by complex mechanisms.
CTCF is a conserved, ubiquitous and multifunctional transcription factor with features of a tumour suppressor.
YY1 is a multifunctional transcription factor that modulates the expression of a wide variety of genes [ 22].
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The bone remodeling microenvironment is a complex system in which the cell functions are controlled by multifunctional transcription factors, cytokines and growth factors.
CBA/SIV altered the expression of 39 genes important for the synthesis of amino acids and nucleic acids, enzymes essential for the proper charging of tRNA and ribosome biogenesis, proteins utilized in the splicing and maturation of mRNA, and multifunctional transcription factors that regulate the initiation of transcription (Additional file 2: Table S2).
The ubiquitous, conserved, multifunctional polycomb transcription factor Yin Yang 1 (YY1) plays a pivotal role in biological processes [ 13- 15].
VIP1 is a multifunctional bZIP transcription factor that stimulates stress- and defense-related gene expression by binding to a specific DNA hexamer motif present in many promoters that respond to activation of the MPK3 pathway, including the PR1 pathogenesis-related gene.
Sox9 is a multifunctional transcriptional factor expressed in both embryonic lung mesenchyme and epithelium.
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