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The Calcium Channels pathway comprises a multifunctional set of genes that regulate intracellular calcium levels (Supplemental Table 2) and plays a role in hormone and neurotransmitter release, muscle contraction, and immune cell activation.
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Broadly defined, this is a field that examines how "… large numbers of functionally diverse, and frequently multifunctional, sets of elements interact selectively and nonlinearly to produce coherent behavior" (Kitano, 2002).
Tech giants like Microsoft, Intel and Cisco will make a lot of noise about convergence with products like Vista, Viiv and multifunctional set-top boxes.
The proposed method is based on a new conceptual model that splits a multifunctional unit into a set of seeds with each functional group, assembling the branched elements after the independent propagation of each seed.
Proper execution of chromosome biorientation and mitotic checkpoint signaling relies on a set of multifunctional kinases, one of which is the dual specificity kinase Mps1 [3].
The KRE2/MNT1 family encode a set of multifunctional mannosyltransferases that participate in O-, N- and phosphomannosylation.
Materials synthesized by living organisms constitute a fantastic source of inspiration for the design of multifunctional materials from a limited set of chemical elements or molecules, whereas traditional industrial preparation methods allow only to design materials with a single function and not able to undergo self-reparation.
However ortholog analysis of each domain within our set of 273 multifunctional proteins against 39 sequenced bacterial and eukaryotic genomes, identified only 18 candidate Rosetta Stone proteins.
They are modular mega-multifunctional enzymes that synthesize an incredibly diverse set of biological active peptides or cyclic lipopeptides (Schwarzer et al. 2003).
Finally, HuR is a multifunctional regulator of RNA stability and recognizes a set of AU-rich sequences using its two N-terminal RRM domains [ 43].
T. fusca possesses a limited set of only six cellulases and does not produce multifunctional enzymes.
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