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In the present work, we have used the functional module approach to identify those multifunctional proteins that exhibit extreme multifunctionality.
Calcium-dependent protein kinases (CDPKs) are multifunctional proteins that combine calcium-binding and signaling capabilities within a single gene product.
Based on this, it has been proposed that viruses manipulate hosts through multifunctional proteins that facilitate exploitation of host resources and elicitation of specific changes in host phenotypes.
Galectins are multifunctional proteins that act as regulators of various biological processes via protein-glycan interactions.
These are multifunctional proteins that are all expressed intracellularly but also on the neuronal cell surface [20, 21].
Transforming growth factor-βs (TGF-βs) are a group of multifunctional proteins that have neuroprotective roles in various experimental models.
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RNase R is a multifunctional protein that exhibits ribonuclease and ribosome recycling factor activities21.
The IAV NS1 protein is a multifunctional protein that has been previously shown to interact with many host cell factors and play important roles in virus replication54.
DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease.
Hepatitis B virus X protein (HBx) is a multifunctional protein that interacts directly with many host proteins.
Growth and differentiation factor-5 (GDF-5) is a multifunctional protein that regulates the development and repair in many tissues.
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