Tissue inhibitors of metalloproteinases (Timp) are multifunctional proteins including four members (Timp1-4).
Several pathogenic protozoa are capable of recognizing iron-containing proteins through multifunctional proteins, including Toxoplasma gondii tachyzoites, which bind B-holo-Lf, B-holo-Tf, and chicken holo-ovo-Tf through one 42-kDa protein, suggesting low-specificity binding [ 37].
Here, positive correlations were observed for the neutrophil count with acute phase reactants S100-A99), IGH1Moglobulins (IGH1M, PIGR), metabolic enzymes (PGAM) as well as other multifunctional proteins including actin-binding protein plastin 2 (PLSL), fibronectin (FINC), CRAMP and PGRP1.
Flii is distributed across many cellular compartments, as would be expected for such a multifunctional protein, including the nucleus, cytosol and lysosomes.
The human fH family consists of seven multi-domain and multifunctional serum proteins, including fH itself (MW 150 kDa), factor H-like protein 1 (FHL-1) (MW 42 kDa) and five factor H-related proteins (FHR-1, -2, -3, -4 and -5) [ 26].
PTMs (post-translational modifications) offer a way to dynamically regulate multifunctional proteins, and many RNA-binding proteins, including those involved in mRNA translation, are subject to complex regulation by phosphorylation.
Transforming growth factor- β (TGF- β) is a group of multifunctional proteins, which include three TGF- β isoforms (TGF- β1, - β2, - β3) and several other polypeptides.
TRANSLATIONAL IMPACT Clinical issue Scaffold attachment binding factors (SAFBs) are a family of multifunctional proteins that include SAFB2, SAFB1 and the scaffold attachment factor-like transcriptional modulator (SLTM).
EGF is a multifunctional growth factor, which causes activation of many cytoskeletal proteins including cofilin.
Therefore, the 30Kc19 protein is a very unique multifunctional protein that can be applied for the delivery of therapeutic proteins including enzymes, as it can penetrate cell membranes and stabilize cargo proteins.
In fact, the only ABCE family member studied to date is a multifunctional protein that includes a metal-binding domain (PF04068) adjacent to the 4Fe-4S bindomainomain (PF00037), as well as two ATP-binding sites/ATPase domains typical of ABC proteins (PF00005) but it lacks transporter domains.
