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Galectin-3 is a multifunctional protein of a growing family of β-galactoside-binding animal lectins, which is implicated in a variety of biological events such as tumor cell adhesion, proliferation, differentiation and angiogenesis.
In addition, they were shown to actively produce and secret cytokines [3] and they are involved in the production of L-PGDS (lipocalin-type prostaglandin D2 synthase or β-trace protein), a multifunctional protein of the CSF [4], [5].
Flightless I (Flii) is a multifunctional protein of the gelsolin family of actin-remodelling proteins.
HBP is a multifunctional protein of inflammation that is responsible for a number of host response mechanisms to infection.
The APOE (Apolipoprotein E) gene encodes apolipoprotein E (ApoE), a multifunctional protein of the lipid and lipoprotein transport system involved mainly in metabolism of dietary lipids.
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We postulated that the novel multifunctional proteins of oomycetes could function as potential Rosetta Stones to identify interacting proteins of conserved metabolic and regulatory networks in other eukaryotic genomes.
For example, duplication could permit each copy of a multifunctional protein to specialize on a subset of the ancestral activities, thereby reducing pleiotropy [ 23, 24].
The aim of the present study is to illustrate the utility of correlative SAR as a strategy to link a specific protein function of a multifunctional protein to an observed cellular phenotype.
Our understanding of the multifunctional protein products of the BRCA1 gene and why defects in the gene result in breast and ovarian cancer is still in a state of flux.
The EWSR1 gene encodes a multifunctional protein, member of the ten-eleven TETnslocation (TET) family of proteins, that is involved in various cellular processes, including gene expression, cell signalling and ribonucleic acid (RNA) processing and transport.
As shown in Figure 1A, DEBS is composed of six multifunctional protein modules, each of which is responsible for a single round of polyketide chain elongation and functional group modification.
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