As a step toward the goal of generalized but targeted protease inhibition in the endocytic pathway, we describe here the synthesis, characterization, and cellular application of a novel multifunctional protease inhibitor.
In particular, the nsp1 and the nsp2 proteases release themselves from the ORF1a polyprotein firstly, and the nsp1 can be further processed into two multifunctional proteases, namely, the nsp1 α and the nsp1 β [ 10, 11].
Serine proteases are multifunctional enzymes that play important roles in the immune response and hemostasis and are considered important allergens with significant IgE binding activity [ 48].
Among the five proteins that were up-regulated, ER-60 protease and P4 hb are multifunctional proteins that belong to the protein disulfide isomerase family that is a chaperone protein and related with tumor cell migration and invasion [ 28- 30].
HIV-1 matrix (MA) is a multifunctional protein that is synthesized as a polyprotein that is cleaved by protease during viral maturation.
Serine proteases (SPs) in the chymotrypsin (S1) family constitute one of the largest gene families of multifunctional enzymes that play important roles in various physiological processes, including digestion, development and the immune response [ 7].
Korotchenko described the MiG 29MM2 as a multifunctional craft that can be used to attack targets on land and sea.
Years later, the cellphone would become an ubiquitous, multifunctional device that, incidentally, showed the time.
"Crisis centres are multifunctional spaces that provide comprehensive housing, psychosocial and legal support.
