In spite of these benefits, the synthetic difficulty and complex surface structure associated with polymer brushes have hindered their utilization for constructing multifunctional, patterned surfaces.
The multifunctional pattern-generating circuits of the brainstem allow rapid modulation of orofacial behaviours (swallowing, respiration, chewing, coughing, and vomiting) [ 5].
The multifunctional patterning peptide was synthesized by a combination of standard Fmoc solid-phase methods, in which the photodegradable azide acid 4- 4- 1- 4-azidobutanoyloxy 4- 4- 1- 4-azidobutanoyloxy 4- 4- 1- 4-azidobutanoyloxy 4- 4- 1- 4-azidobutanoyloxy 4- 4- 1- 4-azidobutanoyloxy ethyl -2-methoxy-5-nitrophenoxy butanoic ethyl -2-methoxy-5-nitrophenoxy butanoic ethyl -2-methoxy-5-nitrophenoxy butanoic ethyl -2-methoxy-5-nitrophenoxy butanoic ethyl -2-methoxy-5-nitrophenoxy butanoic
It is in our future plans to broaden the applicability of these proposed computational tools for studies of neuronal networks, especially for multifunctional central pattern generators comprised of several neurons [2, 46].
Multistability has been reported in several neuronal systems both experimentally and computationally, including individual neurons and their models, as well as in neural networks and multifunctional central pattern generators [1, 46].
Macrophage scavenger receptor A (SR-A) is a multifunctional, multiligand pattern recognition receptor with roles in innate immunity, apoptotic cell clearance, and age-related degenerative pathologies, such as atherosclerosis and Alzheimer's disease.
Collectin-K1 (CL-K1) is a multifunctional secreted pattern-recognition lectin with key roles in host defence, tissue homeostasis and embryogenesis [ 1, 2].
Coupling the toehold-mediated DNA strand-displacement reaction with DNA photolithography enabled the fabrication of a DNA chip surface with multifunctional DNA patterns having complex geometrical structures at the microscale level.
We show here that this vaccine candidate elicits the exact same pattern of multifunctional CD4+ T cells and of focused in vivo DC activation in neonates as in adults.
This integrated model represents the first example of modeling "network level regulatory patterns" of multifunctional pathways.
These results also show that recognition between disordered heteropolymers and multifunctional surfaces due to statistical pattern matching may be a good model to study kinetics in frustrated systems with quenched disorder.
