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QDs also provide a versatile nanoscale scaffold for designing multifunctional nanoparticles with both imaging and therapeutic functions.
The results indicated that the as-synthesized multifunctional nanoparticles with small size, highly solubility in water, and both high MR relaxivities and upconversion luminescence may have potential usage for MR imaging in future.
Each chapter demonstrates multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy as new modalities for cancer theranostics.
In this paper, we report on the interaction of multifunctional nanoparticles with living endothelial cells.
Besides multifunctional nanoparticles with Dox and VLA4-pep conjugates (NPDox/VLA4−pep), other nanoparticles synthesized for control experiments include only Dox conjugated (NPDox), only VLA4-pep conjugated (NPVLA4−pep), Dox and nonspecific peptide conjugated (NPDox/ns), nonspecific-peptide conjugated (NPns) and bare nanoparticles (NPbare).
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Multifunctional nanoparticles integrated with imaging modalities (such as magnetic resonance and optical) and therapeutic drugs are promising candidates for future cancer diagnostics and therapy.
Multifunctional nanoparticles (NPs) with complementary capacities of multimodal imaging and therapeutic functions have drawn extensive attention in biomedical areas [1, 2, 3, 4, 5, 6].
Indeed, multifunctional nanoparticles have been reported with combined upconverting luminescence, magnetic properties, and PTT function.
To validate the therapeutic efficacy of multifunctional nanoparticles, SCID mice were injected with NCI-H929 tumors, and were sorted into four treatment groups: (i) free Dox, (ii) NPDox/VLA4−pep, (iii) NPDox and (iv) PBS (control).
The results of fluorescence spectra showed that the resultant multifunctional nanoparticles exhibited selective turn-on type fluorescence enhancement with Hg2+.
Multifunctional nanoparticles that combine the delivery of therapeutic agents with the capacity for in vivo imaging are attractive as they enable simultaneous monitoring and treatment of diseases.
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