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In summary, this multifunctional nanoparticle system could deliver R848 and DOX respectively to tumor microenvironment and breast cancer cells to achieve synergistic effects of immunotherapy and chemotherapy against breast cancer.
In the present study, a dual pH-responsive multifunctional nanoparticle system was designed for combining immunotherapy and chemotherapy to treat breast cancer through targeting immune cells and cancer cells.
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Multifunctional nanoparticle systems (MFNPSs) have seen a recent increase in the research effort put into the development of newer and improved systems around the world.
Such a nanoparticle system for drug delivery is multifunctional, which provides a platform to formulate anticancer drugs which reduces the side effects of the formulated anticancer drug, promotes synergistic therapeutic effects, and achieves targeted delivery for the therapy.
These results argued for the platform potential of the triple pIX-modified Ad vector in building a multifunctional nanoparticle in cancer gene therapy.
Additional layers are applied to generate a blood-stable and multifunctional nanoparticle via the layer-by-layer (LbL) assembly technique.
We believe, under the nanotechnology and tissue-engineering concepts, our multifunctional nanoparticle scaffold may provide a unique approach to treat angioplasty-induced vascular injury.
Specifically, we address the design of multifunctional nanoparticles as an alternative system for drug and gene delivery, which has great potential for therapy in areas, such as cancer and neuropathologies.
For this reason, using multifunctional nanoparticles in drug delivery systems become more important.[1,2] Some drug molecules are encapsulated nanoparticles as drug delivery systems.[3] Ampicillin is a one of effective antibiotics against Gram-positive and Gram-negative bacteria.
Furthermore, multifunctional magnetic iron oxide composite nanoparticle systems with designed active sites will promise for a various applications, such as catalysts, magnetic recording, bioseparation, biodetection, etc.
In addition, NP-CIK cells also enter into the liver, spleen, kidney, etc.; however, compared with available reports, the amount of gold nanorods loaded with human CIK cells in the tumor site is higher than the amount of antibody-conjugated gold nanorods, which show that human CIK cells should be a good delivery system for multifunctional nanoparticles, therapeutic gene, or drugs.
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