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Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development.
Low density lipoprotein receptor related protein 1 (LRP1) is a multifunctional member of the LDL receptor (LDLR) gene family with a unique capacity of binding over 40 distinct ligands [1].
LRP1 is the most multifunctional member of this superfamily [ 1, 2].
Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family.
Our current understanding of how SAM68, a multifunctional member of the separate STAR (signal transduction and activation of RNA metabolism) family of RBPs, affects key cellular regulatory circuitries and promotes cancer development and progression is summarized by P. Frisone et al. in "SAM68: Signal Transduction and RNA Metabolism in Human Cancer".
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The EWSR1 gene encodes a multifunctional protein, member of the ten-eleven TETnslocation (TET) family of proteins, that is involved in various cellular processes, including gene expression, cell signalling and ribonucleic acid (RNA) processing and transport.
S100 proteins are a family of at least 25 low molecular weight multifunctional members found in vertebrates, with regulatory roles in a variety of cellular processes [ 57, 58].
We also selected tuberous sclerosis protein 1 (TSC1), a multifunctional protein and member of a key pathway implicated in cell growth and metabolism, namely the Akt/TSC1-TSC2/mTOR pathway [ 18].
Lrp4 is a member of the multifunctional low-density lipoprotein receptor (Lldlr) gene family [14] [16].
ADAM9 is a widely expressed and particularly polyvalent member of the multifunctional ADAM family of proteins.
LAMA2 codes laminin alpha 2, a member of the multifunctional laminin family of proteins known to be expressed in periodontal ligament and gingival fibroblasts (Han and Amar 2002).
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