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Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development.
Low density lipoprotein receptor related protein 1 (LRP1) is a multifunctional member of the LDL receptor (LDLR) gene family with a unique capacity of binding over 40 distinct ligands [1].
LRP1 is the most multifunctional member of this superfamily [ 1, 2].
Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family.
Our current understanding of how SAM68, a multifunctional member of the separate STAR (signal transduction and activation of RNA metabolism) family of RBPs, affects key cellular regulatory circuitries and promotes cancer development and progression is summarized by P. Frisone et al. in "SAM68: Signal Transduction and RNA Metabolism in Human Cancer".
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S100 proteins are a family of at least 25 low molecular weight multifunctional members found in vertebrates, with regulatory roles in a variety of cellular processes [ 57, 58].
The EWSR1 gene encodes a multifunctional protein, member of the ten-eleven TETnslocation (TET) family of proteins, that is involved in various cellular processes, including gene expression, cell signalling and ribonucleic acid (RNA) processing and transport.
We also selected tuberous sclerosis protein 1 (TSC1), a multifunctional protein and member of a key pathway implicated in cell growth and metabolism, namely the Akt/TSC1-TSC2/mTOR pathway [ 18].
Preliminary evaluation indicates that the KBS can assist the purchasing team by providing feedback to suppliers, monitoring suppliers against performance benchmarks, improving cooperation between the multifunctional purchasing team members and reduces the time involved in conducting the make or buy evaluation.
β-Arrestins, including four superfamily members, are multifunctional adaptor and scaffold proteins (Lefkowitz and Whalen, 2004).
Tissue inhibitors of metalloproteinases (Timp) are multifunctional proteins including four members (Timp1-4).
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