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Fibroblast growth factor (FGF) is a multifunctional growth factor that induces cell proliferation, survival, migration, and differentiation in various cell types and tissues.
Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that is a well-established modulator of vascular cells [1].
TGF- β is a multifunctional growth factor that regulates cell fate, including EMT and apoptosis.
EGF is a multifunctional growth factor, which causes activation of many cytoskeletal proteins including cofilin.
It is a multifunctional growth factor that regulates proliferation, differentiation of cells, protein synthesis and angiogenesis.
Hepatocyte growth factor (HGF) is a multifunctional growth factor produced by stromal cells.
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AMF/GPI is a multifunctional cytokine that exhibits multifunctional growth factor-like activity via a unique cognate 78 kDa (glycoprotein 78, gp78) seven-transmembrane glycoprotein receptor (autocrine motility factor receptor, AMFR) [ 10].
Provocative mechanistic connections have been made between the steroid hormone superfamily, including the SERMS and retinoids, and the TGF-β family of multifunctional growth factors [ 8].
TGFB1 is the prototype member of the TGFB-superfamily comprising multifunctional growth factors with numerous cell and tissue functions such as cell cycle control, regulation of early development, differentiation, extracellular matrix (ECM) formation and chemotaxis.
As it contains high concentrations of platelets, which can release various kinds of multifunctional growth factors when activated (Table 1), platelet-rich plasma (PRP) represents a new strategy for the biological treatment of IDD [ 5].
BFGF, as a member of the multifunctional fibroblast growth factor family, is highly active both in vivo and ex vivo in enhancing the mitosis, chemotaxis, neurotrophy, and angiogenesis.
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