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Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions.
Clusterin (CLU) is a ubiquitous multifunctional factor involved in neoplastic transformation.
Lactotransferrin (LTF) is another multifunctional factor revealing LPS priming-related upregulated mRNA levels.
Its repeated motives and modularity make Rtx a multifunctional factor in pathogenicity.
Vascular Endothelial Growth Factor (VEGF) is a potent, multifunctional factor, which regulates angiogenesis and blood vessel permeability [ 13, 14].
In consequence, PI3K is a multifunctional factor implicated in cell signaling, intracellular trafficking and actin-membrane reorganization.
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Similarly, it has been shown that GST or GST homology domains can help in complex formation of aaRSs with multifunctional factors (p38, p18) [ 56, 57].
The multifunctional factors Imp-α and Imp-β are involved in nuclear protein import, mitotic spindle dynamics, and nuclear membrane formation.
With clearer understanding of the genuine human ANP32 proteins, we can focus on the best strategies and circumstances to fine-tune these multifunctional factors for desired physiological outcome.
Decreased response to different cytotoxic drugs and gamma irradiation was reported in human glioblastoma cells after treatment with the multifunctional growth factor scatter factor/hepatocyte growth factor, which activates the PI3-K/Akt pathway [ 44].
The multifunctional gene transforming growth factor-β (TGF-β) was also included in order to show whether regenerative and proliferative responses were activated following tissue damage.
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