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Several compounds showed excellent potential as multifunctional compounds for AD.
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The complexity of Alzheimer's disease (AD) calls for search of multifunctional compounds as potential candidates for effective therapy.
Altogether, these scientific findings make these multifunctional compounds potentially valuable drugs for the treatment of Alzheimer's disease.
The inhibitory activity was successfully extended to the beta-site amyloid precursor protein cleavage enzyme, leading to the discovery of a potent inhibitor of this enzyme (3) and affording multifunctional compounds (2, 6, 8) for the treatment of AD.
It is relatively accurate for predicting KH for hydrocarbons, monofunctional compounds, and many multifunctional compounds.
The challenge is to develop system suitable for carrying out biotransformation of larger, more polar, and multifunctional compounds.
This review focuses on a number of such multifunctional compounds that have shown considerable success in experimental studies and that show maximum promise for success in clinical trials.
Our previously developed multifunctional compounds inhibited transformation of monomers into fibrils.
Proanthocyanidins (PACs) are plant-derived, multifunctional compounds that possess high interactivity with extracellular matrix (ECM) components.
The studies indicated that avicins, multifunctional compounds, not only inhibit tumor cell growth but may play a role in the maintenance of cellular homeostasis as well.
The recent development of multifunctional compounds represents a move into that direction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com