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CD44 is a multifunctional cell surface protein involved in proliferation and differentiation, angiogenesis and signaling.
The hyaluronate receptor (CD44) molecule is a multifunctional cell surface protein involved in T cell activation, monocyte cytokine release, fibroblast locomotion, and lymphocyte binding to high endothelial venules.
Aminopeptidase N (APN /CD13, a 150-kDa metalloproteinase, is a multifunctional cell surface aminopeptidase with ubiquitous expression.
Aminopeptidase N (APN/CD13), a 150-kDa metalloprotease, is a multifunctional cell surface aminopeptidase with ubiquitous expression.
CD26 is a multifunctional cell surface glycoprotein with intrinsic dipeptidyl peptidase 4 activity particularly expressed on epithelial cells and lymphocytes [ 9, 17, 18].
CD44, a hyaluronan (HA) receptor, is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival.
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As a multistructural and multifunctional cells surface adhesion molecule, CD44 is involved in cell-cell and cell-matrix interactions [13], [16].
It is the multifunctional cell-surface molecule involved in pathologic properties of cancer cells such as cell proliferation, differentiation, migration, angiogenesis, and chemokines [4 6].
CD26 is a multifunctional cell-surface protein that is variably expressed between different cancers but plays a role in regulating cancer progression and spread [ 15].
In mammals, this multifunctional cell-surface receptor, the largest member of the low-density lipoprotein receptor (LDL-R) family, is a 600 kDa protein (Nykjaer and Willnow, 2002).
Gonzalez Gronow, M., Selim, M. A., Papalas, J. & Pizzo, S. V. GRP78: a multifunctional receptor on the cell surface.
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