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carbon nanotubes as multifunctional carriers for radioisotopes for treatment and imaging [69].
Nanoparticles consisting of hydrophobic and hydrophilic segments have great potential as multifunctional carriers for pharmaceutical and biomedical applications, such as drug, protein, peptide or DNA delivery systems.
Nanodiamonds (NDs) represent an emerging class of carbon nanomaterials that possess favorable physical and chemical properties to be used as multifunctional carriers for a variety of bioactive molecules.
Polymer-shelled and perfluoropentane-cored nanobubbles have also been designed, as versatile multifunctional carriers for the delivery of gases, drugs, and genes; the size range is below 500 nm, with shell thickness in the 30 50 nm range.
Specific examples of theranostic agents currently under investigation include liposomal vesicle formulations containing cytostatic drugs and MR contrast agents [28, 29], carbon nanotubes as multifunctional carriers for radioisotopes for treatment and imaging [30], and dendriworms for efficient delivery of siRNA (small interfering RNA) visualised by optical imaging or MRI [31].
These nanospheres behaved as multifunctional carriers for targeted delivery of anti-cancer drug, doxorubicin (DOX), within Hela cells and thus, these nano-drugs exhibited clear cytotoxicity and inhibition toward Hela cells as compared to normal cell-lines of HEK 293T cells.
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The TPGS-b- PCL-ran-PGA) NPs could funcTPGS-b- PCL-ran-PGAonal carrier for chemoTPGS-b- PCL-ran-PGAnd geneTPGS-b- PCL-ran-PGAry, and offer considerable poTPGS-b- PCL-ran-PGA caNPsdate for in vivo couldr therapy.
We have previously demonstrated the use of MSNPs as a multifunctional carrier for delivery of chemotherapeutic agents to human tumors in nude mice.
Here, we provide a detailed analysis of the multifunctional carriers designed for different types of payloads, surveying the biomaterials used to construct the functional carriers.
Amphiphilic PEG PCL PEI triblock copolymers self-assemble into nano-scaled, positively charged, multifunctional carriers, suitable for drug and gene delivery.
These results implied that TPGS-b- PCL-ran-PGA -based NPs could serve as mulTPGS-b- PCL-ran-PGA -basedceTPGS-b- PCL-ran-PGA -based
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