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These new functional PEG-grafted polyurethanes can potentially form multifunctional bioconjugates for applications as biomaterials and in pharmaceutics.
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The multifunctional bioconjugates were prepared according to two drug design approaches recently developed by our group.
The influence of the multifunctional bioconjugates on the cell adhesion and cell proliferation was studied on Mono Mac 6 human leukemic monocytes.
These results demonstrate that multifunctional bioconjugates containing two different anticancer drugs attached to the same GnRH-III targeting moiety could be successfully prepared and resulted in higher in vitro cytostatic effect than the monofunctional bioconjugates containing either methotrexate or daunorubicin, in particular on HT-29 human colon cancer cells.
Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing two chemotherapeutic agents, daunorubicin and methotrexate, coupled to the GnRH-III decapeptide, which served as a targeting moiety.
The current study reported the synthesis of multifunctional bioconjugate (GNPs-Pep-A) to target the cancer cell.
Wu, C. et al. Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting.
Research from the Cancer Molecular Imaging Chemistry Laboratory (CMICL) entitled "Radiolabeled Affibody-Albumin Bioconjugates for HER2-Positive Cancer Targeting" was featured on the cover of the journal Bioconjugate Chemistry.
Meng, F., Hennink, W. E. & Zhong, Z. Reduction-sensitive polymers and bioconjugates for biomedical applications.
Such examples then can be combined with the information throughout the rest of the book to form the basis for designing new bioconjugates for as-yet undiscovered bioconjugate applications.
In conjunction with techniques for site-specific introduction of aldehydes into proteins, the Pictet-Spengler ligation offers a means to generate stable bioconjugates for medical and materials applications.
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