Our results demonstrate that membrane curvature design rules can deterministically inform the construction of multifunctional antibiotics and thereby broaden the spectrum of activity of single target drugs to bacterial subpopulations such as persisters.
In summary, we have engineered a new multifunctional antibiotic that combines membrane activity with inhibition of protein synthesis.
While you want to avoid increasing the footprint of furniture in a small flat if possible, multifunctional pieces such as this maximise the use of available space.
GDSL lipases/esterases are hydrolytic enzymes that possess multifunctional properties, such as broad substrate specificity, regiospecificity, and stereoselectivity.
Multifunctional cytokines such as interleukin-1 (IL-1) play central roles in vascular inflammation.
Albumin is the most abundant plasma protein with multifunctional properties such as ligand-binding and transport, maintaining the colloid osmotic pressure of plasma, and regulating neutrophil function [1].
Finally, AM is multifunctional peptide (such as antiproliferative, antimigrative, anti-inflammatory, antiapoptotic, and antifibrotic effects) [ 1, 4].
Hence, classical neofunctionalization has fallen out of favor in preference for models that begin with the duplication of a multifunctional protein, such as 'specialization' and 'subfunctionalization' models.
CysG converts uroporphyrinogen III, which is a precursor of heme and cobalamin (vitamin B12), to siroheme using multifunctional activities such as SAM-dependent methylase, dehydrogenase and ferrochelatase [ 32].
Therefore, for detailed analysis of multifunctional genes, such as the components of the Ras-MAPK pathway described below, simultaneous time-specific and cell-specific knockdown is necessary.
