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These data provide a strong justification for a multifactorial trial to help define which combinations of azilsartan medoxomil and amlodipine will provide optimal safety and efficacy in the treatment of hypertension.
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They could also allow smaller plot size in multifactorial trials in which fully randomized or randomized block designs are recommended.
S-LK planned and organised the multifactorial prevention trial.
We believe that randomised multifactorial intervention trials to prevent falls in mild-moderate dementia should now be made a priority.
randomized, embedded, multifactorial, adaptive platform trial.
To describe the implementation and the effects of a multifactorial fall prevention trial on the specified risk factors of falling, incidence of falls and injurious falls, and on specified secondary outcome measures; to describe the design of the study and to assess the success of randomization.
The study is a part of a single-centre, risk-based, multifactorial randomised controlled trial.
Sjösten et al. studied subjective and objective predictors of adherence in a multifactorial falls prevention trial [ 29].
A risk-based, multifactorial randomised controlled trial among the previously fallen community-dwelling aged was conducted in Pori, in western Finland.
The success of belimumab and the absence of efficacy above standard of care from the rituximab clinical trials may be multifactorial and may dependent on trial design, but these results could suggest that efficacy in treating SLE may not solely be a function of reductions in B cell numbers.
A randomized trial with multifactorial analysis is necessary to investigate these aspects of PT.
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