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The patients were allocated standard treatment or intensive multifactorial treatment.
Both groups also received multifactorial treatment with tocolytic agents, broad-spectrum antibiotics, and indomethacin.
However, further studies are needed to establish the effect of intensified multifactorial treatment on DN with overt proteinuria.
In group 1, a higher percentage of patients treated with cerclage received antibiotics and indomethacin than did control subjects (P <.01), whereas in group 2, the use of multifactorial treatment was not different (P =.5).
All received intensive multifactorial treatment.
All patients received multifactorial treatment for the prevention of CAD.
Intensive multifactorial treatment might be burdensome for patients who are largely asymptomatic.
General practitioners were randomized to provide intensive multifactorial treatment or routine care.
The remaining 80 patients were assigned to intensive multifactorial treatment at the Steno Diabetes Center.
In the elderly there is usually more than one etiologic mechanism, requiring a multifactorial treatment approach.
3– 6 Further, a small (n = 160) trial of multifactorial treatment found a protective effect at 13 years.
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