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Phenotype is a multifactorial trait that often results from the contribution of many proteins.
ARHI is a complex, multifactorial trait that is attributable to confounding intrinsic and extrinsic factors.
The molecular causes of idiopathic short stature are multiple [ 2], as expected for a multifactorial trait that is influenced both by individual genotypes and environmental factors [ 3].
The large number of replicated SNPs provides further support for the hypothesis that exceptional longevity is a multifactorial trait that is determined in part by an enrichment for common genetic variants imparting protective effects [ 1, 7, 8].
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In particular, although knowledge of the determinants of healthy aging is limited, healthy aging of centenarians is a multifactorial quantitative trait that is influenced by biological, environmental, and psychosocial factors [ 10].
The traits characterized range from being tightly associated biochemically to the interacting mutations and mitochondrial function, such as mitochondrial translation and OXPHOS enzyme activity, to multifactorial behavioral traits that differ in their energy demands, such as flight and climbing.
It is the association of SNPs with polygenic and multifactorial traits however, that has received the most attention in recent years.
The advantage of this method is that it offers an unsupervised hypothesis-free network-based gene screening to select probe sets associated with a trait that makes it particularly suitable for multifactorial mRNA studies.
Impulsivity is a multifactorial trait characterized by unplanned responding and hasty decision making that may be unduly risky or neglect negative consequences.
All together, these results indicate that virulence is, in Xenorhabdus as in many other pathogens, a multifactorial trait.
In summary, our study provides evidence that GWAS scan has a potential to identify novel genetic components contributing to a complex multifactorial trait such as BP.
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