Hayreh investigated the correlation between nocturnal dips in arterial blood pressure and predisposition to NAAION, postulating that hypotension may be the 'final insult in a multifactorial situation' [ 2].
Similar to other studies, the challenges to ART adherence among ALHIV were multifactorial and included family situations, socioeconomic factors, medication issues and healthcare systems [ 40– 40].
Many reviews and editorials have highlighted the recent lack of new antibiotics, and the causes of this situation are multifactorial but may lie in two or three areas: namely regulatory uncertainty, poor economic evaluations and potentially even local "bad governance" (Collignon et al., 2015).
It is important to reinforce the idea that the survival of individuals who are seropositive for HIV-1 is accompanied by a chronic infectious process and continuous treatments with side effects, exposing these individuals to a number of complex situations that are multifactorial and interrelated, such as inflammation, atherosclerosis, and dyslipidemia.
This is probably the expected situation in a multifactorial and complex disease such as ASD, a group of different conditions with overlapping phenotype generated each from a single or, more frequently, a combination of genetic changes with possible environmental contribution as well.
In most other situations, however, particularly those concerning multifactorial diseases such as cancer and psychiatric disorders, there are usually numerous contributing factors for the observed phenotype, but their relative importance is not always known beforehand.
The literature identifies separate indices for use in clinical and laboratory situations and specific indices for attrition, abrasion, erosion and multifactorial tooth wear.
S. cerevisiae grows far better at acidic than neutral or alkaline pH and consequently even a modest alkalinization of the medium represents a stress situation that is able to trigger a compensatory multifactorial response (for a review see [ 16]).
Barriers to HIV and TB testing are multifactorial, and TB screening methods have limitations; nonetheless, in this situation, there were several missed opportunities for diagnosis of TB and HIV that could have prevented this patient's death.
