Upon chronic exposure to minimal doses of hydrogen peroxide, SH-SY5Y cells displayed a multifactorial response to the stressor.
The end result would be a multifactorial response leading to 5FU resistance.
This highlights the potential impact of genetic factors, biologic variation, and multifactorial considerations in the response of tendons to overuse and rest.
Recent transcript profiling studies have shown that the molecular response of plants to multifactorial stress cannot be directly extrapolated from the response to single applied stress [ 59– 63].
A multifactorial design of response surface methodology was used to model linear, interaction, and quadratic effects of these variables on steady shear rheological properties of ayran samples and in situ EPS production levels.
Atherosclerosis is a progressive disease characterized by the response of the vessel wall to chronic, multifactorial injury, which leads ultimately to the formation of atheromatous or fibrous plaques.
33 47 For example, the multifactorial cascade of responses induced by hypoxia including angiogenesis, glucose transport, glycolysis and pH regulation, may partially explain improved high-intensity endurance performance independent of a greater Hbmass.
The identification of a proteomic biomarker in this work is an important further step in the direction of response prediction in RA and in the design of a multidisciplinary biomarker set that takes in account the multifactorial nature of the response prediction.
This study used a multifactorial design to examine the cellular responses of Staphylococcus aureus to hydrogen peroxide (0 100 mM) when bacteria were grown in temperatures of 37 ± 2 °C and pH 7 ± 1, conditions potentially encountered in wound sites.
Moreover, insight into the structure of mutual protein-protein interactions can provide direct information into multifactorial stimulation-response relations which are crucial for experimental design in drug research and therapies.
