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Not all migraineurs find the current medication options effective, which perhaps highlight the multifactorial pathophysiology of migraine and suggest that individual environmental and/or genetic factors may influence treatment response [4].
Our results show the multifactorial pathophysiology of SMA, whereby EVH and IVH play a particularly important role.
The results obtained by our group demonstrate the role of genetics in the multifactorial pathophysiology of breast malignant neoplasms.
The low concordance among A1C-, IFG-, and IGT-based diagnosis of pre-diabetes highlights the multifactorial pathophysiology of glucose dysfunction.
This may be difficult to prove given the complex multifactorial pathophysiology of AKI, and it is likely that intervening on a single pathway may be ineffectual.
However, due to the complex and multifactorial pathophysiology of the disease, other drugs (e.g. exogenous surfactant) should be included in the therapeutic scheme, too.
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Clustering of CVRF may occur in type 1 diabetes [ 12, 13], analogously to the one known as metabolic syndrome in type 2 diabetes, but there is a different multifactorial pathophysiology for the clustering in each of the two major types of diabetes [ 12, 14, 15].
In sum, genetically predisposed individuals for T2D with deteriorating glucose tolerance exhibit insulin resistance as well as beta-cell and signs of adipose tissue dysfunction, emphasizing the multifactorial pathophysiology in the development of IGT and T2D.
These results probably reflect both the multifactorial pathophysiology underlying the development of WMLs and the methodological differences regarding assessment of PWV and WML.
It might reflect the multifactorial pathophysiology underlying the development of WMLs.
In conclusion, individuals with a family history of type 2 diabetes and deteriorating glucose tolerance, showed insulin resistance as well as beta cell and possibly also adipose tissue dysfunction, emphasizing the multifactorial pathophysiology in the development of IGT and T2D.
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