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Low back pain is acknowledged widely to be a multifactorial pathology with a variety of symptoms, dysfunctions, and a number of possible sources of pain.
Traumatic brain injury (TBI) is a multifactorial pathology with great interindividual variability in response to injury and outcome.
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Inflammatory bowel diseases (IBD) are described as multifactorial pathologies with an uncontrolled immune response leading to inflammation in genetically predisposed individuals.
Alzheimer's disease (AD) is a multifactorial pathology that requires multifaceted agents able to address its peculiar nature.
Symptomatic osteoarthritis (OA) is now widely accepted as being a multifactorial pathology affecting the whole joint complex [ 1].
HSP has a multifactorial pathology in which a wide variety of pathogens, drugs, and other environmental exposures have been involved [ 3].
In complex multifactorial pathologies, such as multiple sclerosis, numerous mechanisms may ameliorate disease.
Obesity is a pathology with multifactorial causes that is characterized by an increase in fat body mass and is linked to a significant increase in morbidity and mortality.
Nonetheless, it is now apparent that CD4+ T cells individually are unable to drive this multifactorial autoimmune pathology.
Therefore, we hypothesized that loss of SigR1 function contributes to a vicious circle including ER stress, defective autophagy and altered calcium signaling that causes multifactorial ALS pathology.
Such strategies are increasingly relevant for the development of successful combination therapies for patients suffering from complex, multifactorial cardiometabolic pathologies.
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