Such findings support the multifactorial model of gastric pathology that includes the host, H. pylori, and the environment [ 13, 36, 39].
However, we would like to emphasize that dendritic spine loss is only one part of the underlying multifactorial pathology of AD that contributes to cognitive decline besides neuron death, tauopathy, and hyperexcitability, to mention just some.
It is a pathology that cannot be cured".
Still, the complexity of this multifactorial pathology reduces the translatability to clinical practice of data derived from genetically-modified animals because therapeutic interventions targeting these specific genes do not take into account other contributing genes that participate in the pathogenesis of the disease (Miller et al. 2013).
Low back pain is acknowledged widely to be a multifactorial pathology with a variety of symptoms, dysfunctions, and a number of possible sources of pain.
Traumatic brain injury (TBI) is a multifactorial pathology with great interindividual variability in response to injury and outcome.
Symptomatic osteoarthritis (OA) is now widely accepted as being a multifactorial pathology affecting the whole joint complex [ 1].
HSP has a multifactorial pathology in which a wide variety of pathogens, drugs, and other environmental exposures have been involved [ 3].
In complex multifactorial pathologies, such as multiple sclerosis, numerous mechanisms may ameliorate disease.
Inflammatory bowel diseases (IBD) are described as multifactorial pathologies with an uncontrolled immune response leading to inflammation in genetically predisposed individuals.
