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However, we would like to emphasize that dendritic spine loss is only one part of the underlying multifactorial pathology of AD that contributes to cognitive decline besides neuron death, tauopathy, and hyperexcitability, to mention just some.
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Low back pain is acknowledged widely to be a multifactorial pathology with a variety of symptoms, dysfunctions, and a number of possible sources of pain.
Still, the complexity of this multifactorial pathology reduces the translatability to clinical practice of data derived from genetically-modified animals because therapeutic interventions targeting these specific genes do not take into account other contributing genes that participate in the pathogenesis of the disease (Miller et al. 2013).
HSP has a multifactorial pathology in which a wide variety of pathogens, drugs, and other environmental exposures have been involved [ 3].
Alzheimer's disease (AD) is a multifactorial pathology that requires multifaceted agents able to address its peculiar nature.
It is a complex multifactorial pathology, in which genetic and environmental factors, like smoking, can play an important role in the onset of disease and the progression of the joint damage [ 1, 2].
Traumatic brain injury (TBI) is a multifactorial pathology with great interindividual variability in response to injury and outcome.
Symptomatic osteoarthritis (OA) is now widely accepted as being a multifactorial pathology affecting the whole joint complex [ 1].
This hypothesis, however, does not imply that elevated HIF activity is toxic per se but that it may be one of several factors contributing to multifactorial pathologies found in diseases such as dry AMD.
In complex multifactorial pathologies, such as multiple sclerosis, numerous mechanisms may ameliorate disease.
As AD is multifactorial, no single biomarker will be able to explain the progression or pathology of AD and hence single biomarker approaches have been unsuccessful in predicting the disease pattern.
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