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These findings are compatible with the multifactorial model and provide an example of the interaction of genetic and environmental factors.
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In general, our data are well in line with the multifactorial model of fears and phobias (Muris and Merckelbach 2001).
Wilber and Pitsiladis [ 33] proposed a multifactorial model taking genetic, physiological and psychological factors into account.
A multifactorial model linking tooth size and number can account for the different patterns of expression of tooth size, hypodontia and supernumerary teeth observed in males and females.
GPs who provide a diagnosis tend to have a broader, multifactorial, model of the condition and more positive attitudes towards CFS/ME.
We consider that a multifactorial model – with genetic, epigenetic and environmental influences – provides the best explanation for our observations involving differences of expression of hypodontia and supernumerary teeth in MZ twin pairs (Fig. 1).
We believe that such a multifactorial model, with multiple genetic, epigenetic and environmental influences, provides the best explanation for our observations involving missing and extra teeth in MZ twin pairs.
Rather than a simple monogenic mode of inheritance alone, we consider that a multifactorial model 7,45,83 – with genetic, epigenetic and environmental influences – provides the best explanation for our observations involving hypodontia and supernumerary teeth in MZ twin pairs, as well as different phenotypic expressions in MZ co-twins with ectodermal dysplasia.
Commingling analyses indicated that a three-component distribution model best accounts for the variation in age of onset of oesophageal cancer, and that a multifactorial model provides the best fit to the general population data.
Moore and Stuart (2005) take a bio-psycho-social perspective toward the relationship between drugs and violence that posits a multifactorial model whereby the risk of violence increases as a result of both distal (biological and developmental factors) and proximal (environmental) factors.
Additionally, the study will provide preliminary data of associations among hypothesized predictors, mediators and moderators of pregnancy weight gain and postpartum weight loss and retention, in accordance with the multifactorial model shown in Figure 1.
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