Bearing in mind that most of the type 2 diabetes patients are treated in a primary care setting, and that a better metabolic control can reduce their complications, a reduction in the burden of diabetes mellitus should be achieved with a more efficient implementation of multifactorial management at primary level.
These improvements can be attributed to the wide implementation of multifactorial management, which had been shown to decrease substantially both morbidity and mortality, associated with T2D [ 11].
Thus, patients should receive early, intensive and multifactorial management, targeting all risk factors simultaneously, to prevent or slow the progression of kidney disease.
In view of the current definition of sepsis in children and infants where SIRS plus infection equals sepsis, it is crucially important to recognize systemic inflammatory response syndrome (SIRS) patients in everyday practice and to appreciate the importance of multifactorial management of the potential sepsis sufferer.
Patients with peripheral vascular disease (PVD) are likely to be influenced more favourably by surgical procedures and multifactorial management.
The most likely reason is differences in multifactorial management strategies that in turn influence prevention of orthopaedic injury or strategies that makes it possible to keep horses longer.
This suggests that the multifactorial management of type 2 diabetes should incorporate routine blood pressure lowering and more intensive glucose control to reduce the burden of adverse clinical sequelae in individuals with established diabetes.
However, many patients still develop ESRD and CVD despite improvements in their outcome resulting from recent aggressive multifactorial management (4– 6).
Multifactorial management includes intensive treatment and implementation of strict targets for cardiovascular risk factors (CRF), namely, hyperglycemia, hypertension, dyslipidemia and prothrombotic state [ 2].
Diabetes is a complex disease and necessitates a multifactorial approach to management.
