The aetiology of this cancer is thought to be multifactorial, with malaria and Epstein Barr virus (EBV) infections being two well-documented co-factors (reviewed in Rochford et al, 2005; Kelly and Rickinson, 2007), although it is likely that there are other co-factors.
Considering the multifactorial character of malaria, the purpose of the present study was to validate these findings by generalizing our analysis to an Indian population with different genetic background, endemic and environmental status.
Although the etiology of anemia is complex and multifactorial, parasitic diseases, including malaria and intestinal parasites are recognized as the major cause of anemia in endemic countries [32], [33].
Prolonged anaemia following parasite clearance in falciparum malaria is multifactorial.
Anemia in malaria is multifactorial and mainly due to haemolysis and dyserythropoiesis [ 39].
The anaemia associated with falciparum malaria is multifactorial and is thought to be due to greater destruction of unparasitized red blood cells compared to parasitized red blood cells, and bone marrow dyserythropoiesis of variable intensity and duration [ 16– 18, 37– 37].
The pathogenesis of AKI in severe malaria is multifactorial, and these factors include various inflammatory mediators, intravascular hemolysis and coagulation, hypovolemia from dehydration, hyperparasitemia, and immune complexes, among others [ 3].
The circumstances leading to higher parasite burdens in severe malaria are likely multifactorial and incompletely understood.
This multifunctional attribute of these hybrid compounds makes them potential drug candidates for the treatment of multifactorial diseases such as cancer, Alzheimer's disease, metabolic syndromes, AIDS, malaria, and cardiovascular diseases.
9, 10 The reasons for the lack of change are multifactorial, ranging from health system factors to the underlying high intensity of malaria transmission.
