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The U-CARE program is a complex, multifactorial intervention with multiple components.
The Steno-2 trial of 160 type 2 diabetic patients with microalbuminuria showed that an 8-year multifactorial intervention with glycemic control, RAS blockers, aspirin, and lipid lowering led to a 46% reduction in all-cause mortality after an additional 5-year period of observation (26).
Intensified multifactorial intervention, with tight glucose regulation and the use of renin-angiotensin system blockers, aspirin, and lipid-lowering agents, and behavior modification have sustained beneficial effects with respect to vascular complications and a lower risk of death from CV causes (43, 44).
11, 12 In Steno-2, investigators used intensified multifactorial intervention with improved glycemia, renin angiotensin system blockers, aspirin, and lipid-lowering agents and evaluated whether this approach would have an effect on the rates of death from cardiovascular causes and from any cause.
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Type 2 diabetic patients should undergo intensive multifactorial interventions with individual targets for the prevention of macrovascular diseases.
As the post-WWII Baby Boom generation approaches old age, there is an urgent need to improve our understanding of the causes of falls and enhance the multifactorial interventions with a more enriched knowledge base.
Patients with short-duration type 2 diabetes should receive an intensive multifactorial intervention approach with individual targets for the prevention of macrovascular diseases.
Intensified multifactorial intervention in patients with type 2 diabetes with microalbuminuria slows the progression to nephropathy, and progression of retinopathy and autonomic neuropathy.
In Steno-2 (Intensified Multifactorial Intervention in Patients with Type 2 Diabetes and Microalbuminuria), patients with T2DM and persistent microalbuminuria were randomized to receive either conventional intervention involving multiple risk factors, or intensified, targeted, multifactorial intervention involving a combination of medications and focused behavior modification.
Primary prevention of macrovascular diseases can be achieved through intensified, multifactorial intervention in patients with short-duration type 2 diabetes.
In conclusion, the primary prevention of macrovascular disease could be achieved through intensified, multifactorial intervention in patients with type 2 diabetes.
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